The structure of the conserved neurotrophic factors MANF and CDNF explains why they are bifunctional
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چکیده
منابع مشابه
The structure of the conserved neurotrophic factors MANF and CDNF explains why they are bifunctional.
We have solved the structures of mammalian mesencephalic astrocyte-derived neurotrophic factor (MANF) and conserved dopamine neurotrophic factor (CDNF). CDNF protects and repairs midbrain dopaminergic neurons in vivo; MANF supports their survival in culture and is also cytoprotective against endoplasmic reticulum (ER) stress. Neither protein structure resembles any known growth factor but the N...
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ژورنال
عنوان ژورنال: Protein Engineering, Design and Selection
سال: 2009
ISSN: 1741-0134,1741-0126
DOI: 10.1093/protein/gzn080